Higher prevalence in elderly - Multi-drug usage, lots of polypharmacy - Drug-disease interaction due to lots more comorbidities - Worse pharmacokinetics
Only really seen with SSRI + SNRI. Mirtazapine does not appear to contribute in combination.
Differences in management - Avoid combination antidepressant prescribing if possible - Follow guidelines regarding antidepressant switching. Most cases of
Last modified: Wed Sep 18 22:41:14 2024